期刊
BRAIN RESEARCH
卷 1090, 期 -, 页码 23-28出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2006.02.138
关键词
Ginkgo; ischemia/reperfusion; bax/bcl-2 ratio; SAMP8; brain
In the present studies, we investigated the molecular mechanism of one of the active ingredients of Ginkgo biloba, EGb761, to affect the levels of several apoptotic markers in six brain regions following global ischemia in senescence-accelerated mice. A 4-day treatment with EGb761 significantly decreased bax/bcl-2 ratios in all brain regions in both young and aged mice. Our findings indicate that the bax/bcl-2 ratio provides a suitable index of apoptosis and modulation of these markers may explain the neuroprotective action of EGb761.
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