期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 105, 期 3, 页码 421-426出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2005.11.019
关键词
Leontopodium alpinum; anti-inflammatory activity; analgesic activity; antioxidant activity; intestinal propulsion; Edelweiss
Dichloromethane, methanolic and CO2 extracts of the aerial parts and roots of Edelweiss (Leontopodium alpinum Cass.) were investigated for their anti-inflammatory and analgesic effects after oral administration. The highest activity in rat's paw edema assay was found for the lipophilic extracts of the aerial plant parts (dose 200mg/kg), exhibiting a swelling reduction of 72% (CO2-extract) and 80% (DCM-extract), respectively. Histological evaluation of the treated paws showed a significant reduction of the inflammatory response in the pre-treated specimens. On the contrary in the acetic acid-induced writhing test the dichloromethane extract of the root extract exhibited more pronounced analgesic effects than the extracts of the aerial parts, suggesting a different pattern of active compounds. As far as gastrointestinal effects are concerned, oral administration of aerial parts (hDCM 200 mg/kg) to mice induces a highly significant inhibition in gastrointestinal propulsion probably related to the presence of so far unknown compounds. Moreover, the antioxidant capacity of some extracts was studied in order to establish a possible correlation with anti-inflammatory properties. (c) 2006 Published by Elsevier Ireland Ltd.
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