期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 12, 期 16, 页码 4431-4445出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200501397
关键词
alcohols; asymmetric catalysis; C-C coupling; enantioselectivity; titanium
The catalytic enantioselective addition of different organozinc reagents (such as alkyl and aryl derivatives or in situ generated aryl, allyl alkenyl, and alkynyl derivatives obtained through different transmetallation processes) to simple ketones has been accomplished by using titanium tetra-isopropoxide and chiral ligands derived from substituted trans-1-sulfonyl amino-2-isoborneolsulfonylaminocyclohexane, producing the corresponding tertiary alcohols with enantiomeric excesses (ee) up to > 99%. A simple and efficient procedure for the synthesis of the chiral ligands used in these reactions is described.
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