期刊
VIROLOGY
卷 349, 期 1, 页码 142-155出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2006.02.006
关键词
proviral load; HIV-1; subtype C; T cell responses; human
类别
资金
- FIC NIH HHS [TW00004] Funding Source: Medline
- NIAID NIH HHS [AI43255, AI47067] Funding Source: Medline
- NICHD NIH HHS [HD37793] Funding Source: Medline
We investigated the interactive relationship between proviral DNA load and virus-specific IFN-gamma-secreting T cell responses in HIV-1C infection. The presence or absence of correlation, and inverse or direct type of correlation, if any, were dependent on targeted viral gene product. Responses to Gag p24 or to Pol were associated with lower proviral DNA load. Associations between proviral DNA load and T cell responses did not necessarily mirror relationships between plasma RNA load and T cell responses. An interaction analysis showed a synergy in that lower proviral DNA and lower plasma RNA load were associated with high Gag p24-specific IFN-gamma-secreting T cell response (interaction test P = 0.0003). Our findings support the idea that HIV proteins have differential value for vaccine design, and suggest that, for HIV-1C, Gag p24 may be one of the most attractive regions to include in vaccine designs to control both plasma RNA load and cell-associated proviral DNA load. (c) 2006 Elsevier Inc. All rights reserved.
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