期刊
NATURE
卷 441, 期 7092, 页码 532-536出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature04794
关键词
-
资金
- NIGMS NIH HHS [R01 GM062207] Funding Source: Medline
During meiosis, cohesins-protein complexes that hold sister chromatids together-are lost from chromosomes in a step-wise manner(1). Loss of cohesins from chromosome arms is necessary for homologous chromosomes to segregate during meiosis I. Retention of cohesins around centromeres until meiosis II is required for the accurate segregation of sister chromatids. Here we show that phosphorylation of the cohesin subunit Rec8 contributes to step-wise cohesin removal. Our data further implicate two other key regulators of meiotic chromosome segregation, the cohesin protector Sgo1 and meiotic recombination in bringing about the step-wise loss of cohesins and thus the establishment of the meiotic chromosome segregation pattern. Understanding the interplay between these processes should provide insight into the events underlying meiotic chromosome mis-segregation, the leading cause of miscarriages and mental retardation in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据