Development of nonproprietary phosphine ligands for the Pd-catalyzed amination reaction

A new family of pyrazole and bi-pyrazole phosphine ligands are reported that perforin efficiently in the Pd-catalyzed amination reaction. Of the ligands screened, ligand 1 emerged as the most compatible for couplings involving both primary and secondary amines with typical yields of 84-99%. (c) 2006 Elsevier Ltd. All rights reserved.