期刊
VACCINE
卷 24, 期 22, 页码 4804-4811出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2006.03.021
关键词
superinfection; polymicrobial disease; conjugate vaccine; LPD
Passive transfer of a pediatric human serum pool generated against polysaccharide-protein D conjugate vaccines conferred similar to 34% protection against development of ascending NTHI-induced OM when used in a chinchilla viral-bacterial co-infection model. These data are in line with results obtained using a similar 11-valent-protein D conjugate vaccine in a pediatric clinical trial, wherein a vaccine efficacy of 35.6% was shown against acute OM episodes caused by NTHI. These observations strongly support the chinchilla passive transfer-superinfection model as one that could predict clinical trials outcomes for vaccines to prevent NTHI-induced OM. (c) 2006 Elsevier Ltd. All rights reserved.
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