4.5 Article

Differentiation of monocyte-derived dendritic cells is associated with upregulation and activation of Rac-1 small GTPase

期刊

FEBS LETTERS
卷 580, 期 13, 页码 3335-3339

出版社

WILEY
DOI: 10.1016/j.febslet.2006.04.095

关键词

dendritic cells; Rac-1; interleukin-4; interferon-alpha; cytoskeleton; small GTPases

向作者/读者索取更多资源

Critical changes occurring in Rac-1 molecule, a cytoskeleton organizing small GTPase associated with cell ruffling, have been analyzed in dendritic cells (DCs) derived from monocytes cultured with granulocyte-macrophage colony-stimulating factor and IFN-alpha or IL-4. Although with different kinetics, both agents induced activation of Rac-1 molecule and, more importantly, an upregulation of both protein expression and mRNA transcription. These findings strengthen the role of Rac-1 molecule in the induction of DC differentiation and suggest that, besides its activation, the upregulation of Rac-1 molecule might also play a role in the acquisition of DC mature phenotype. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据