期刊
FEBS LETTERS
卷 580, 期 13, 页码 3335-3339出版社
WILEY
DOI: 10.1016/j.febslet.2006.04.095
关键词
dendritic cells; Rac-1; interleukin-4; interferon-alpha; cytoskeleton; small GTPases
Critical changes occurring in Rac-1 molecule, a cytoskeleton organizing small GTPase associated with cell ruffling, have been analyzed in dendritic cells (DCs) derived from monocytes cultured with granulocyte-macrophage colony-stimulating factor and IFN-alpha or IL-4. Although with different kinetics, both agents induced activation of Rac-1 molecule and, more importantly, an upregulation of both protein expression and mRNA transcription. These findings strengthen the role of Rac-1 molecule in the induction of DC differentiation and suggest that, besides its activation, the upregulation of Rac-1 molecule might also play a role in the acquisition of DC mature phenotype. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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