期刊
JOURNAL OF PROTEOME RESEARCH
卷 5, 期 6, 页码 1344-1353出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr050414x
关键词
aging; myosin; phosphorylation; 2-D DIGE; mass spectrometry
The aim of the present study was to assess age-dependent changes of proteins in the vastus lateralis muscle of physically active elderly and young subjects by a combination of two-dimensional difference gel electrophoresis, SDS-PAGE and ESI-MS/MS. The differences observed in the elderly group included down-regulation of regulatory myosin light chains, particularly the phosphorylated isoforms, a higher proportion of myosin heavy chain isoforms 1 and 2A, and enhanced oxidative and reduced glycolytic capacity.
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