期刊
NATURE GENETICS
卷 38, 期 6, 页码 617-619出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1800
关键词
-
资金
- Medical Research Council [G0000934] Funding Source: Medline
- Wellcome Trust [068545/Z/02] Funding Source: Medline
- Medical Research Council [G0000934] Funding Source: researchfish
- MRC [G0000934] Funding Source: UKRI
In this study we report convincing statistical support for a sixth type 1 diabetes (T1D) locus in the innate immunity viral RNA receptor gene region IFIH1 (also known as mda-5 or Helicard) on chromosome 2q24.3. We found the association in an interim analysis of a genome-wide nonsynonymous SNP (nsSNP) scan, and we validated it in a case-control collection and replicated it in an independent family collection. In 4,253 cases, 5,842 controls and 2,134 parent-child trio genotypes, the risk ratio for the minor allele of the nsSNP rs1990760 A -> G (A946T) was 0.86 (95% confidence interval = 0.82-0.90) at P = 1.42 x 10(-10).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据