期刊
TRANSPLANTATION PROCEEDINGS
卷 38, 期 5, 页码 1293-1294出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.transproceed.2006.02.081
关键词
-
Background. Advances in transplantation medicine are linked to improved efficacy of immunosuppressive agents. At the same time, these agents endanger medical success by side effects that may impair survival and quality of life (QOL). This study examined whether conversion to tacrolimus-based immunosuppression due to cyclosporine-related side effects improved. QOL in patients after kidney transplantation. Methods. In total 64 patients (29 men) with an average age of 51 years (SD +/- 12) who had received a kidney allograft an average of 5.6 years (SD 4) before conversion participated. The reasons for conversion were cardiovascular/metabolic (n = 26) or periodontal/dermatological side effects (n = 38) of cyclosporine therapy. QOL was assessed before conversion and in average 7 months thereafter by a global (SF-36) and a disease-specific instrument (ESRD-SCL). Results. Disease-specific QOL (ESRD-SCL, global index) improved significantly (P < .001, explanation of variance [EV] = 16.6%) after conversion from cyclosporine to tacrolimus. In detail, cardiac and renal dysfunction (P < .01, EV = 12.9%) as well as increased growth of gum and hair (P < .0001, EV = 53.2%) were significantly reduced at end of the study. However, global QOL (SF-36) remained unchanged. Conclusion. Regardless of the indication (cardiovascular or cosmetic), switching to tacrolimus due to cyclosporine-related side effects improved disease-specific QOL within the short term.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据