期刊
CLINICAL NUTRITION
卷 25, 期 3, 页码 418-427出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2005.10.011
关键词
cystic fibrosis; arachidonic acid; eicosapentaenoic acid; docosapentaenoic acid; leukotriene B-4; leukotriene B-5
Background & aims: Various anti-inflammatory therapies, including dietary omega-3 polyunsaturated fatty acids (PUFA) supplementation, have been investigated in cystic fibrosis (CF) patients. To further explore this nutritional approach, biological effects of an omega-3 PUFA oral liquid supplementation were measured in 17 CF patients in a double-blind, randomized, crossover without a washout period and placebo-controlled study. Methods: CF patients (age: 18 +/- 9 year; weight: 43 +/- 13 kg) received a liquid dietary supplementation either enriched or not in omega-3 PUFA (390-1170 mg/day according to patient weight) during two 6-month periods. Results: Increase in eicosapentaenoic acid was observed in neutrophil membrane following omega-3 PUFA dietary supplementation (from 0.7 +/- 0.6 to 1.6 +/- 0.6 mu mol%, P < 0.01). The leukotriene B-4 (LTB4)/leukotriene B-5 (LTB5) ratio was decreased (from 72 +/- 27 to 24 +/- 7, P < 0.001) in CF patients taking omega-3 PUFA supplements. In contrast, omega-3 PUFA supplementation affected neither internalization of IL-8 receptors following IL-8 exposure, nor IL-8-induced neutrophil chemotaxis. Conclusion: Our results show that omega-3 PUFA are incorporated in neutrophil membranes. The subsequent decrease in LTB4/LTB5 ratio suggests that, in such conditions, neutrophils may produce less pro-inflammatory mediators from the acid arachidonic pathway. These data indicate that omega-3 PUFA intake may have antiinflammatory effect that still need to be assessed by long-term studies following large groups of patients. (C) 2005 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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