期刊
CHEMOSPHERE
卷 64, 期 1, 页码 121-128出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2005.10.045
关键词
biomarkers; aquatic worms; oxidative stress; total soluble protein; gulathione-S-transferase (GST); catalase activities (CAT); metallothioneins
Metallothioneins (MTs), are low molecular weight proteins, mainly implicated in metal ion detoxification. Increase in MT contents is considered as a specific biomarker of metal exposure. Recently it has been demonstrated that MTs participate in several cellular functions such as regulation of growth, and antioxidative defences. Tubifex tubifex were exposed to different copper concentrations (50, 100, and 200 mu g 1(-1)) for 7 and 15 days. MT levels in exposed worms increased significantly (p < 0.05) after 7 and 15 days of exposure to different concentrations of copper (maximum +208% for 100 mu g 1(-1) after 7 days of exposure). Also important perturbation in metal-metallothionein content occurred, along with an increase in total soluble protein content in all treated worms after 7 and 15 days (max. +88.49%). Catalase activities (CAT) in Cu treated-worms were significantly increased, and demonstrated a development of antioxidative defenses. Additionally a reduction of gulathione-S-transferase (GST) was observed in all treated worms after 7 days of exposure to Cu (max. -44.42%). The high induction of MTs observed during T. tubifex exposure to Cu make them potentially useful biomarkers to monitor metal pollution. (c) 2005 Elsevier Ltd. All rights reserved.
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