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BRITISH POULTRY SCIENCE
卷 47, 期 3, 页码 357-364出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00071660600756071
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1. Our objective was to evaluate the toxic effects of aflatoxin B-1 (AFB(1)) and fumonisin B, (FBI), administered singly or in combination to broilers. 2. Feeds were prepared with concentrations equal to 0, 50 and 200 mu g AFB(1)/kg, and/or 0, 50 and 200 mg FB1/kg, and offered to broiler chicks from 8 to 41 d of age. The experimental design was totally randomised, in a 3 x 3 factorial arrangement with 9 treatments and 12 birds per treatment. Animals were vaccinated against Newcastle disease on d 14 of life and killed at 41 d. 3. Compared with controls, all mycotoxin-treated groups at 41 d had lower body weight and weight gain, and higher relative heart weight. The relative weight of the liver increased only in birds fed diets containing 200 mg FBI, singly or in combination with AFB(1). 4. At 35 d, all groups receiving mycotoxin-treated rations had reduced geometrical mean antibody titres, with birds from groups fed combinations of AFB(1) and FB1/kg having even lower values, when compared to the other groups. 5. Histological changes were observed only in liver from birds fed mycotoxin-contaminated rations, and in kidneys of birds fed the diet containing 200 mu g AFB(1) and 200 mg FB1/kg. Main alterations included vacuolar degeneration and cell proliferation of bile ducts in the liver, and hydropic degeneration in renal tubules in the kidneys. 6. We concluded that AFB(1) and FB1 in combination have primarily additive effects on body weight, liver structure and immunological response of broilers at the concentrations used.
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