期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 78, 期 6, 页码 1053-1059出版社
UNIV CHICAGO PRESS
DOI: 10.1086/504160
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资金
- Medical Research Council [G19/9, G9505090] Funding Source: researchfish
- Medical Research Council [G19/9, G9505090] Funding Source: Medline
- Wellcome Trust [074586] Funding Source: Medline
- MRC [G19/9, G9505090] Funding Source: UKRI
Haplotype-based techniques are being used to estimate the relative age of alleles-particularly in screening loci for signals of recent positive selection-but does this approach capture even coarse age differences? Using simulations and empirical data from the International HapMap Project, we show that a simple pairwise metric of haplotype homozygosity gives significantly higher mean values for human single-nucleotide-polymorphism alleles that appear to be derived than for those that appear to be ancestral, as determined by comparison with the chimpanzee genome. Our results support the use of haplotype-based techniques, such as extended haplotypic homozygosity, to assess the age of alleles.
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