期刊
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
卷 26, 期 6, 页码 373-379出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jir.2006.26.373
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The first line of defense against viral infections is mediated by interferons (IFN)s, which are produced rapidly by the infected host. Type I IFNs (IFN-alpha/beta) are known to combat viruses both directly by inhibiting viral replication in the cells and indirectly by stimulating the innate and adaptive immune responses. Recently, a novel class of cytokines was discovered and named IFN-lambda (alternatively type III IFN or interleukin-28/29 [IL-28/ 29]), based on IFN-like antiviral activity and induction of typical IFN- inducible genes. Here, we review the literature on IFN-lambda and discuss the current knowledge of the functions and mechanisms of action of IFN-lambda.
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