期刊
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
卷 85, 期 2, 页码 76-83出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.pestbp.2005.10.005
关键词
biochemical; resistance; mechanism; housefly; pyraclofos; in vivo; in vitro; metabolism
In vivo and in vitro metabolism of pyraclofos labeled with C-14 on benzene ring was studied in the pyraclofos-resistant and -susceptible female houseflies. In vivo metabolism studies, the metabolic rate of pyraclofos was the same in both strains. Pyraclofos primarily undergoes metabolic detoxification by cleavage of P-S-alkyl bond, and cleavage of the P-O-aryl bond followed by CHP [1-(4-chlorophenyl)-4-hydroxypyrazole]]-glucose conjugation. Cleavage of P-O-aryl bond and CHP glucose conjugation is more predominant in the resistant strain whereas the cleavage of P-S-propyl bond resulting in EHP-CHP [O-1-(4-chlorophenyl)pyrazol-4-yl ethyl hydrogen phosphate] is more preferred in the susceptible strain. CHP production by P-O-aryl bond cleavage was controlled by P450 monooxygenase and esterase. UDP-glucosyltransferase appeared to play an important role in the pyraclofos metabolism of the resistant strain. Production of CHP-glucose conjugate was largely reduced by piperonyl butoxide and S,S,S-tributylphosphorotrithioate in both strains. EHP-CHP production seemed to be controlled by P450 monooxygenase and stimulated by UDP-glucose. (c) 2005 Elsevier Inc. All rights reserved.
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