期刊
NATURE IMMUNOLOGY
卷 7, 期 6, 页码 625-633出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1337
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- NHLBI NIH HHS [N01-HV-28179] Funding Source: Medline
- NIAID NIH HHS [AI41109, AI20038] Funding Source: Medline
- NIDDK NIH HHS [DK068292] Funding Source: Medline
Ligation of the B cell antigen receptor (BCR) with antigen induces lipid raft coalescence, a process that occurs after crosslinking of a variety of signaling receptors and is thought to potentiate cellular activation. To investigate lipid raft dynamics during BCR signaling, we quantitatively analyzed the B cell lipid raft proteome. BCR engagement induced dissociation of the adaptor protein ezrin from lipid rafts as well as threonine dephosphorylation of ezrin and its concomitant detachment from actin, indicating a transient uncoupling of lipid rafts from the actin cytoskeleton. Expression of constitutively active ezrin chimeras inhibited the BCR-induced coalescence of lipid rafts. Our data demonstrate that the release of ezrin from lipid rafts acts as a critical trigger that regulates lipid raft dynamics during BCR signaling.
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