期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 11, 页码 2915-2919出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.03.009
关键词
oleanolic acid; glycogen phosphorylase; inhibitor; derivatives; diabetes
Oleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50 = 3.3 mu M) is the most potent GPa inhibitor. Preliminary structure-activity relationships of the oleanolic acid derivatives are discussed. (c) 2006 Elsevier Ltd. All rights reserved.
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