期刊
IMMUNOGENETICS
卷 58, 期 5-6, 页码 471-473出版社
SPRINGER
DOI: 10.1007/s00251-006-0104-7
关键词
IL-18; HIV-1 infection; Brazilian children; promoter polymorphism; single-tube allele-specific PCR
In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the -607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism.
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