期刊
NATURE NEUROSCIENCE
卷 9, 期 6, 页码 729-731出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1696
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资金
- NIMH NIH HHS [5T32MH018264-22, 5F31MH069089-02, 5R01MH068542-03] Funding Source: Medline
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.
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