期刊
BIOMACROMOLECULES
卷 7, 期 6, 页码 1735-1742出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm060024j
关键词
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资金
- NIBIB NIH HHS [R21 EB004589-01A1] Funding Source: Medline
Side-chain-functionalized lactide analogues have been synthesized from commercially available amino acids and polymerized using stannous octoate as a catalyst. The synthetic strategy presented allows for the incorporation of any protected amino acid for the preparation of functionalized diastereomerically pure lactide monomers. The resulting functionalized cyclic monomers can be homopolymerized and copolymerized with lactides and then quantitatively deprotected forming new functional poly(lactide)-based materials. This strategy allows for the introduction of functional groups along a poly(lactide) (PLA) backbone that after deprotection can be viewed as chemical handles for further functionalization of PLA, yielding improved biomaterials for a variety of applications.
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