期刊
IEEE JOURNAL OF SOLID-STATE CIRCUITS
卷 41, 期 6, 页码 1471-1480出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSSC.2006.874331
关键词
bioelectronics; biolab-on-IC; cell manipulations; CMOS integrated circuits; digital logic; integrated circuits; lab-on-a-chip; microcoil arrays; microcoils; microfluidics; SiGe integrated circuits
This paper introduces an integrated circuit (IC)/microfluidic hybrid system for magnetic manipulation of biological cells. The hybrid system consists of an IC and a microfluidic system fabricated on top. Biological cells attached to magnetic beads are suspended inside the microfluidic system that maintains biocompatibility. The IC contains a microcoil array circuit that produces spatially-patterned microscopic magnetic fields. Programmable, rapid reconfiguration of the field pattern made possible by the IC allows an efficient simultaneous manipulation of multiple individual bead-bound cells with precise position control. Two prototypes, SiGe/microfluidic and CMOS/microfluidic hybrid systems, validate the proposed approach.
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