期刊
ANNALS OF ONCOLOGY
卷 24, 期 6, 页码 1675-1679出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdt016
关键词
brain tumors; dental X-ray exposure; Taiwan Health Insurance
类别
资金
- China Medical University Hospital [DMR-100-076, DMR-100-077]
- Taiwan Department of Health Clinical Trial and Research Center for Excellence [DOH102-TD-B-111-004]
- Taiwan Department of Health Cancer Research Center for Excellence [DOH102-TDC--111-005]
- International Research-Intensive Centers of Excellence in Taiwan (I-RiCE)
- National Science Council [NSC101-2911-I-002-303]
Background: This study evaluates the risk of benign brain tumors (BBTs) and malignant brain tumors (MBTs) associated with dental diagnostic X-ray, using a large population-based case-control study. Materials and methods: We identified 4123 BBT cases and 16 492 controls without BBT (study 1) and 197 MBT cases and 788 controls without MBT (study 2) from Taiwan National Health Insurance claim data. The risks of both types of tumor were estimated in association with the frequency of received dental diagnostic X-ray. Results: The mean ages were similar to 44.2 years in study 1 and 40.6 years in study 2. Multivariable unconditional logistic regression analysis showed that the risk of BBT increases as the frequency of received dental diagnostic X-ray increases. The BBT odds ratio increased from 1.33 [95% confidence interval (CI) 1.22-1.44] for those with annual mean X-ray examination of less than one to 1.65 (95% CI 1.37-1.98) for those with three or more X-ray examinations, after controlling for comorbidities. No significant association was found between MBTs and dental diagnostic X-ray exposure. Conclusions: Exposure to dental diagnostic X-rays in oral and maxillofacial care increases the risk of BBTs, but not MBTs.
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