期刊
ANNALS OF ONCOLOGY
卷 23, 期 9, 页码 2442-2449出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdr610
关键词
concordance evaluation; histological review; medical decision; molecular biology; sarcoma
类别
资金
- Merck Serono
- French National League against Cancer (Ain and Rhone committees)
- Detect, Analyse, Inform, Sarcomas (DAM'S)
- Infosarcome and Sarcoma Patient Euronet (SPAEN)
- Commission of the European Communities, Connective Tissue Cancer Network [CONTICANET FP6-018806]
- Lyon Integrated Research Cancer Centre (LYRIC)
- Sarcoma Clinical Reference Network (Netsarc)
- Reference Network in Sarcoma pathologies (REPPS)
- French National Cancer Institute (INCa)
Sarcomas represent a heterogeneous group of tumors. Accurate determination of histological diagnosis and prognostic factors is critical for the delineation of treatment strategies. The contribution of second opinion (SO) to improve diagnostic accuracy has been suggested for sarcoma but has never been established in population-based studies. Histological data of patients diagnosed with sarcoma in Rhone-Alpes (France), Veneto (Italy) and Aquitaine (France) over a 2-year period were collected. Initial diagnoses were systematically compared with SO from regional and national experts. Of 2016 selected patients, 1463 (73%) matched the inclusion criteria and were analyzed. Full concordance between primary diagnosis and SO (the first pathologist and the expert reached identical conclusions) was observed in 824 (56%) cases, partial concordance (identical diagnosis of connective tumor but different grade or histological subtype) in 518 (35%) cases and complete discordance (benign versus malignant, different histological type or invalidation of the diagnosis of sarcoma) in 121 (8%) cases. The major discrepancies were related to histological grade (n = 274, 43%), histological type (n = 144, 24%), subtype (n = 18, 3%) and grade plus subtype or grade plus histological type (n = 178, 29%). More than 40% of first histological diagnoses were modified at second reading, possibly resulting in different treatment decisions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据