期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 21, 期 6, 页码 934-945出版社
WILEY
DOI: 10.1359/JBMR.060311
关键词
Dickkopf; Wnt; LRP5; osteoblast; osteoporosis
Wnt/beta-catenin signaling has been proven to play a central role in bone biology. Unexpectedly, the Wnt antagonist Dkk2 is required for terminal osteoblast differentiation and mineralized matrix formation. We show that Dkk1, unlike Dkk2, negatively regulates osteoblast differentiation and bone formation.
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