期刊
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
卷 173, 期 11, 页码 1186-1193出版社
AMER THORACIC SOC
DOI: 10.1164/rccm.200510-1584PP
关键词
asthma; cystic fibrosis; pulmonary hypertension; S-nitrosoglutathione; S-nitrosohemoglobin; S-nitrosylation
资金
- NHLBI NIH HHS [R01 HL 69170, 2R01 HL59337] Funding Source: Medline
- NIGMS NIH HHS [K08 GM 069977] Funding Source: Medline
Genetic and biochemical data demonstrate a pivotal role for S-nitrosothiols (SNOs) in mediating the actions of nitric oxide synthases (NOSs). SNOs serve to convey NO bioactivity and to regulate protein function. This understanding is of immediate interest to the pulmonary clinical and research communities. This article reviews the following: (1) biochemical and cellular evidence that SNOs in amino acids, peptides, and proteins elicit NOS-dependent signaling in the respiratory system and (2) studies that link SNO signaling to pulmonary medicine. SNO-mediated signaling is involved in the regulation of minute ventilation, ventilation-perfusion matching, pulmonary arterial pressure, basal airway tone, and respiratory and peripheral muscle function. Derangements in SNO signaling are implicated in many disorders relevant to pulmonary and critical care medicine, including apnea, hypoxemia, pulmonary hypertension, asthma, cystic fibrosis, pneumonia, and septic shock.
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