期刊
ANNALS OF ONCOLOGY
卷 23, 期 1, 页码 186-192出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdr057
关键词
folate; head and neck cancer; MTHFR; prognosis; TYMS
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [221S0001]
- Ministry of Health, Labour and Welfare of Japan
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [221S0001] Funding Source: KAKEN
Background: The association between dietary folate intake, two polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS), and survival in head and neck squamous cell carcinoma (HNSCC) patients is not clarified. Patients and methods: We conducted a retrospective cohort study of 437 HNSCC patients treated at Aichi Cancer Center. We evaluated the survival impact of pretreatment dietary folate intake, which was estimated using a food-frequency questionnaire, and two polymorphisms, MTHFR C677T and a 6-bp insertion/deletion in the 3'-untranslated region of TYMS, using multivariate proportional hazard models. Results: Patients with high folate intake (>= 320 mu g/day; n = 144) had significantly higher survival than patients with low or medium folate intake (<320 mu g/day; n = 278; 79.1% versus 68.2%, respectively, P = 0.020). This association was consistent with multivariate analyses adjusted for established prognostic factors (hazard ratio 0.56; 95% confidence interval 0.37-0.84). MTHFR and TYMS polymorphisms did not show significant association with survival, although the TYMS 6-bp insertion allele showed potential association with a reduced risk of death. Notably, no significant interaction was observed between folate intake and the two examined polymorphisms. Conclusions: High pretreatment dietary folate intake was identified as an independent prognostic factor associated with improved clinical outcomes in HNSCC patients. Further study is warranted.
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