期刊
ANNALS OF ONCOLOGY
卷 23, 期 4, 页码 1030-1036出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdr300
关键词
angiogenesis; contrast-enhanced ultrasound (CEUS); DCE-MRI; EndoTAG-1; liver metastasis; pharmacokinetic profile
类别
资金
- MediGene AG, Germany
Background: EndoTAG-1 (ET), a novel formulation of cationic liposomes carrying embedded paclitaxel (Taxol), shows antitumoral activity, targeting tumor endothelial cells in solid tumors. Patients with advanced metastatic cancer were evaluated investigating effects on pharmacokinetics and tumor vasculature using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and contrast-enhanced ultrasound (CEUS). Patients and methods: The pharmacokinetic (PK) profile of ET (22 mg/m(2) i.v.) was evaluated after single and repeated doses. DCE-MRI and CEUS explored hepatic metastases before, during and after the 4-week treatment cycle. Angiogenic biomarkers were assessed. Tumor response was evaluated by modified RECIST. Results: The PK profile demonstrated slight accumulation of paclitaxel after repeated doses. DCE-MRI parameters K-trans and/or iAUC(60) showed a trend to decrease. Changes of blood flow-dependent parameters of DCE-MRI and CEUS were well correlated. Angiogenic biomarkers revealed no clear trend. ET was generally well tolerated; common toxic effects were fatigue and hypersensitivity reactions. Nine (9 of 18) patients had stable disease after the first treatment cycle. Four patients without disease progression continued treatment. Conclusions: This study including multiple pretreated patients with different metastatic cancer revealed individually distinctive hemodynamic alterations by DCE-MRI. The PK profiles of ET were similar as observed previously.
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