期刊
ANNALS OF ONCOLOGY
卷 23, 期 5, 页码 1320-1324出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdr384
关键词
Helicobacter pylori; noncardia gastric cancer; prospective study; western blot
类别
资金
- Spanish Ministry of Health [Exp P10710130]
- La Caixa [BM 06-130]
- Red Tematica de Investigacion Cooperativa en Cancer (Spain) [R06/0020]
- European Commission (DGSANCO)
- International Agency for Research on Cancer
- Spanish Ministry of Health, Regional Government of Andalucia
- Spanish Ministry of Health, Regional Government of Austrias
- Spanish Ministry of Health, Regional Government of Catalunya
- Spanish Ministry of Health, Regional Government of Basque Country
- Spanish Ministry of Health, Regional Government of Murcia
- Spanish Ministry of Health, Regional Government of Navarra (Spain)
- Danish Cancer Society (Denmark)
- Liguecontre le Cancer
- 3M
- Mutuelle Generale de l'Education Nationale
- Institut National de la Sante et de la Recherche Medicale (France)
- Deutsche Krebshilfe
- Deutsches Krebsforschungszentrum
- Federal Ministry of Education and Research (Germany)
- Ministry of Health and Social Solidarity
- Stavros Niarchos Foundation and Hellenic Health Foundation (Greece)
- Italian Association for Research on Cancer (AIRC)
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare and Sports (VWS)
- Netherlands Cancer Registry (NKR)
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands (The Netherlands)
- Norwegian Cancer Society (Norway)
- Swedish Cancer Society
- Swedish Scientific Council
- Regional Government of Skane and Vasterbotten (Sweden)
- Cancer Research UK
- Medical Research Council
- Stroke Association
- British Heart Foundation
- Department of Health, Food Standards Agency
- Wellcome Trust (UK)
- European Commission
- Medical Research Council [MC_U106179471, G0401527, G1000143] Funding Source: researchfish
In epidemiological studies, Helicobacter pylori infection is usually detected by enzyme-linked immunosorbent assay (ELISA). However, infection can spontaneously clear from the mucosa during the progression of atrophy and could lead to substantial under-detection of infection and underestimation of its effect on gastric cancer (GC) risk. Antibodies detected by western blot are known to persist longer after the loss of the infection. In a nested case-control study from the Eurogast-EPIC cohort, including 88 noncardia GC cases and 338 controls, we assessed the association between noncardia GC and H. pylori infection comparing antibodies detected by western blot (HELICOBLOT2.1) to those detected by ELISA (Pyloriset EIA-GIII((R))). By immunoblot, 82 cases (93.2%) were H. pylori positive, 10 of these cases (11.4%) were negative by ELISA and only 6 cases (6.8%) were negative by both ELISA and immunoblot. Multivariable odds ratio (OR) for noncardia GC comparing immunoglobulin G positive versus negative by ELISA was 6.8 [95% confidence interval (CI) 3.0-15.1], and by immunoblot, the OR was 21.4 (95% CI 7.1-64.4). Using a western blot assay, nearly all noncardia GC were classified as H. pylori positive and the OR was more than threefold higher than the OR assessed by ELISA, supporting the hypothesis that H. pylori infection is a necessary condition for noncardia GC.
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