期刊
INTERNATIONAL JOURNAL OF UROLOGY
卷 13, 期 6, 页码 834-837出版社
WILEY
DOI: 10.1111/j.1442-2042.2006.01418.x
关键词
adenovirus; gene therapy; prostate cancer
There is no effective therapy for hormone-refractory prostate cancer and a novel therapeutic modality, such as a gene therapy, should be actively pursued. Previously, Gardner and Chung conducted a phase I clinical trial of Ad-OC-TK (recombinant adenoviral vector containing osteocalcin promoter-driven herpes simplex virus thymidine kinase gene) plus VAL (valacyclovir) for the treatment of hormone-refractory prostate cancer at the University of Virginia. We report on our ongoing phase I/II clinical trial of Ad-OC-TK plus VAL for the treatment of advanced prostate cancer at the Kobe University Hospital, Japan.
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