期刊
ANNALS OF ONCOLOGY
卷 23, 期 4, 页码 948-U7出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdr350
关键词
imaging; metastatic colorectal cancer; response evaluation; survival
类别
资金
- Swedish Cancer Society [09-0551]
- Stockholm Cancer Society [101131]
- Stockholm county council
- Karolinska Institute
- Sanofi-Aventis
- Pfizer
- Hirofumi Fujii, Functional Imaging Division, National Cancer Center East, Chiba, Japan
Background: To determine whether the change in tumor diameters at the first follow-up computed tomography (CT) examination after baseline examination (first change) correlates with outcome in patients with metastatic colorectal cancer (mCRC) treated with combination chemotherapy. Patients and methods: The first change was analyzed in a multicenter randomized phase III trial (Nordic VI, N = 567) comparing first-line irinotecan with either bolus or infused 5-fluorouracil. Cox proportional hazards multiple regression model and Kaplan-Meier survival analyses after correction for guarantee-time bias were carried out to evaluate correlations between first change, objective response according to RECIST 1.0, progression-free survival (PFS), and overall survival (OS). Results: The hazard ratios for PFS and OS decreased along with first change. A decrease between 10% and <30%, albeit RECIST does not regard this as a partial response, was a positive prognostic factor for PFS and OS. Patients who had new lesions or unequivocal progression of nonmeasurable lesions had a worse prognosis than those with only an increase in size of >20%. Conclusions: The change in tumor size at the first follow-up CT is strongly prognostic for PFS and OS in mCRC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据