期刊
JOURNAL OF VIROLOGY
卷 80, 期 12, 页码 6093-6105出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00205-06
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资金
- NHLBI NIH HHS [R01 HL059725, HL59725] Funding Source: Medline
- NIAID NIH HHS [P30 AI027742, AI27742, R01 AI036085, AI36085] Funding Source: Medline
- NIGMS NIH HHS [GM-46192, R01 GM046192] Funding Source: Medline
Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.
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