期刊
ANNALS OF ONCOLOGY
卷 21, 期 10, 页码 1961-1966出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdq210
关键词
HPV; oropharyngeal carcinoma; p16; prognosis; staging
类别
Patients and methods: Immunohistochemistry for p16 was carried out on the basis of a tissue microarray including 102 OPSCC patients with corresponding retrospective clinicopathological and follow-up data. Results: p16 is the strongest independent prognostic marker in OPSCC, surpassing the significance of cT and cN classification as well as the clinical stages I-IV. Prognosis of p16-positive OPSCC of an advanced stage reached or even exceeded prognosis of the next clinically smaller conventionally staged group of tumors. Conclusion: p16 is the most relevant prognostic marker in OPSCC and should be considered for inclusion into the official staging system of HNSCC.
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