期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 18, 期 6, 页码 433-440出版社
WILEY
DOI: 10.1111/j.1365-2982.2006.00800.x
关键词
breath test; diabetes; gastric emptying; hypoglycaemia
We hypothesize that hypoglycaemia in insulin-treated diabetic patients may result from gastric emptying abnormalities causing insulin and food absorption mismatching. We tested gastric emptying in insulin-treated diabetic patients with unexplained hypoglycaemia and without dyspepsia and in diabetic patients without hypoglycaemia, prospectively. Thirty-one diabetic patients with unexplained hypoglycaemic events within 2 h of insulin injection and 18 insulin-treated diabetic patients without hypoglycaemic events underwent gastric emptying breath tests, glycaemic control and autonomic nerve function. Gastric emptying tests were abnormal in 26 (83.9%) and in four (22.2%) patients with and without hypoglycaemia, respectively (P < 0.001). Gastric emptying was significantly slower in hypoglycaemic diabetic patients (t(1/2) 139.9 +/- 74.1 vs 77.8 +/- 23.3 and t(lag) 95.8 +/- 80.3 vs 32.84 +/- 16.95 min, P < 0.001 for both comparisons; t-tests). A significant association between hypoglycaemic patients and abnormal values of t(1/2) and t(1ag) was found (P < 0.001). Gastric emptying abnormalities were more frequent in hypoglycaemic patients, We suggest gastric emptying tests for diabetic patients with unexplained hypoglycaemic events.
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