期刊
ACTA NEUROCHIRURGICA
卷 148, 期 6, 页码 677-679出版社
SPRINGER WIEN
DOI: 10.1007/s00701-006-0772-y
关键词
Pentosan polysulphate; prion disease; variant; Creutzfeldt-Jakob disease
Pentosan polysulphate, delivered by chronic intraventricular infusion, has been proposed as a potential therapy for human prion disease. The first treated patient is still alive several years after treatment started. Here we describe in detail a case of variant Creutzfeldt-Jakob disease in which this treatment was started at a relatively early stage but had no definite clinical benefit. The patient died from disease progression 16 months after diagnosis and 5 months after pentosan polysulphate treatment was commenced.
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