期刊
ANNALS OF ONCOLOGY
卷 20, 期 9, 页码 1589-1595出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdp029
关键词
DCE-MRI; HAI FUDR; hepatocellular carcinoma; intrahepatic cholangiocarcinoma
类别
资金
- NCI NIH HHS [R21CA121553-01A1] Funding Source: Medline
Patients and methods: Thirty-four unresectable patients (26 ICC and eight HCC) were treated with HAI FUDR/dex. Radiologic dynamic and pharmacokinetic parameters related to tumor perfusion were analyzed and correlated with response and survival. Results: Partial responses were seen in 16 patients (47.1%); time to progression and response duration were 7.4 and 11.9 months, respectively. Median follow-up and median survival were 35 and 29.5 months, respectively; 2-year survival was 67%. DCE-MRI data showed that patients with pretreatment integrated area under the concentration curve of gadolinium contrast over 180 s (AUC 180) > 34.2 mM center dot s had a longer median survival than those with AUC 180 < 34 mM center dot s (35.1 versus 19.1 months, P = 0.002). Decreased volume transfer exchange between the vascular space and extracellular extravascular space (-delta K-trans) and the corresponding rate constant (-delta k(ep)) on the first post-treatment scan both predicted survival. Conclusions: In patients with unresectable primary liver cancer, HAI therapy can be effective and safe. Pretreatment and early post-treatment changes in tumor perfusion characteristics may predict treatment outcome.
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