期刊
ENDOCRINOLOGY
卷 147, 期 6, 页码 S25-S32出版社
ENDOCRINE SOC
DOI: 10.1210/en.2005-1117
关键词
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资金
- Intramural NIH HHS Funding Source: Medline
The term endocrine-disrupting chemicals is used to define a structurally diverse class of synthetic and natural compounds that possess the ability to alter various components of the endocrine system and potentially induce adverse health effects in exposed individuals and populations. Research on these compounds has revealed that they use a variety of both nuclear receptor-mediated and non-receptor-mediated mechanisms to modulate different components of the endocrine system. This review will describe in vitro and in vivo studies that highlight the spectrum of unique mechanisms of action and biological effects of four endocrine-disrupting chemicals diethylstilbestrol, genistein, di(n-butyl)phthalate, and methoxyacetic acid - to illustrate the diverse and complex nature of this class of compounds.
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