期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 21, 期 3, 页码 313-325出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360600741834
关键词
3-(arylmethylene)naphtho[2,1-b]furan-2(3H)-ones; 2-(arylmethylene)naphtho[2,1-b]furan-3(2H)-ones; Knoevenagel coupling; cytotoxicity evaluation
New series of 2(or 3)-arylmethylenenaphtho[2,1-b]furan-3(or 2)-ones were synthesized, characterized and tested for anticancer properties in vitro . The target compounds were prepared by Knoevenagel coupling between the naphthofuranones 3, 28-30 and formyl derivatives. 2-(4-Oxo-1-benzopyran-3-ylmethylene)naphtho[2,1-b]furan-3-one 36 was the most active compound (IC50 (L1210) = 1.6 mu M). These compounds were also evaluated, in an independent manner, as inhibitors of Src protein tyrosine kinase, but only minor activity was observed.
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