期刊
BEHAVIORAL NEUROSCIENCE
卷 120, 期 3, 页码 535-541出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.120.3.535
关键词
abuse liability; dependence; benzodiazepine receptor agonist; long term
资金
- NIDA NIH HHS [K05 DA017918] Funding Source: Medline
The acute and chronic effects of ramelteon, an MT1/MT2 receptor agonist, were evaluated in rhesus monkeys (Macaca mulatta) to assess discriminative stimulus effects in comparison with traditional benzodiazepine receptor agonists and to assess physical dependence potential. Discriminative effects of ramelteon were compared with midazolam in untreated monkeys and in diazepam-dependent monkeys that discriminated flumazenil. Dependence potential of ramelteon after daily 1-year administration (and intermittent discontinuation) was evaluated with standard operant procedures. Ramelteon did not produce benzodiazepine-like discriminative stimulus effects at doses up to 10 mg/kg. Long-term treatment or its discontinuation had no significant effect on spontaneous behavior, operant behavior, body weight, motor activity, or posture. These findings suggest that ramelteon is not likely to have benzodiazepine-like abuse or dependence liability.
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