期刊
JOURNAL OF INFECTIOUS DISEASES
卷 193, 期 11, 页码 1478-1486出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/503780
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Background. We wished to determine recurrences of bacterial vaginosis (BV) after treatment over the course of 12 months and to establish factors associated with recurrence. Methods. Women with symptomatic BV ( a Nugent score [NS] of 7 - 10 or of 4 - 6 with >= 3 Amsel criteria) were enrolled. BV was treated with 400 mg of oral metronidazole twice a day for 7 days. Participants completed a questionnaire and vaginal swabs were collected at 1, 3, 6, and 12 months; the study end point was an NS of 7 - 10. Results. A total of 121 (87%) women with an NS of 7 - 10 and 18 (13%) with an NS of 4 - 6 and >= 3 Amsel criteria were enrolled; 130 (94%) returned >= 1 vaginal samples. Sixty-eight women (58% [95% confidence interval {CI}, 49% - 66%]) had a recurrence of BV ( NS 7 - 10), and 84 (69% [ 95% CI, 61% - 77%]) had a recurrence of abnormal vaginal flora ( NS 4 - 10) by 12 months. A past history of BV, a regular sex partner throughout the study, and female sex partners were significantly associated with recurrence of BV and abnormal vaginal flora by multivariate analysis; the use of hormonal contraception had a negative association with recurrence. Conclusion. Current recommended treatment is not preventing the recurrence of BV or abnormal vaginal flora in the majority of women; factors associated with recurrence support a possible role for sexual transmission in the pathogenesis of recurrent BV.
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