4.6 Article

Post-training intra-striatal scopolamine or flupenthixol impairs radial maze learning in rats

期刊

BEHAVIOURAL BRAIN RESEARCH
卷 170, 期 1, 页码 148-155

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ELSEVIER
DOI: 10.1016/j.bbr.2006.02.010

关键词

acetylcholine; dopamine; flupenthixol; learning; paradoxical sleep window; radial maze; scopolamine; striatum

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Systemic treatments with acetylcholine (ACh) or dopamine (DA) receptor antagonists during hours 0-4 but not during hours 5-8 following training on a radial arm maze (RAM) or lesions of the dorsal striata impair learning. This suggested that intra-striatal infusions of ACh or DA receptor antagonists during hours 0-4 following training may impair learning. Rats were randomly assigned to groups (ns = 5-11) receiving dorsal striatal infusions of the ACh receptor antagonist scopolamine (0-18 mu g/mu L at 0 and 2 h or at 4 and 6 h after training), the DA receptor antagonist cis-flupenthixol (0-25 mu g/mu L at 0, 4 or 12 h after training) or the inactive isomer trans-flupenthixol (6 mu g/mu L at 0 h after training). Scopolamine and cis-flupenthixol impaired the habit-learning version of the task. Given after hours 0-4 following training, the effects of scopolamine were diminished but those of cis-flupenthixol were not. Trans-flupenthixol produced less impairment than cis-flupenthixol. Results suggest that ACh and DA receptors in the dorsal striatum during hours 0-4 following training play a role in habit learning. (c) 2006 Elsevier B.V. All rights reserved.

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