期刊
ORGANIC LETTERS
卷 8, 期 12, 页码 2643-2645出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol0608799
关键词
-
资金
- NIGMS NIH HHS [R01 GM028663-27, GM 28553, R01 GM028663] Funding Source: Medline
An approach to the total synthesis of the antimicrotubule agent welwistatin is described. Key transformations include (1) a 7-endo intramolecular conjugate addition reaction of enone 6 to deliver the strained bicyclo [4.3.1] decanone 5; (2) a 6 pi electrocyclic ring closure of trienecarbamate 16 followed by oxidation to afford protected aniline 17; and (3) an intramolecular cyclization of acetic acid derivative 18 to give rise to indole 19.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据