期刊
SCIENCE
卷 312, 期 5779, 页码 1530-1533出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1124226
关键词
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资金
- Intramural NIH HHS [Z99 AI999999] Funding Source: Medline
Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV) - infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4(+) T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.
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