期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 281, 期 23, 页码 15593-15596出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R500030200
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资金
- NHLBI NIH HHS [HL45100] Funding Source: Medline
- NIGMS NIH HHS [GM29860] Funding Source: Medline
Protein-tyrosine phosphatases are key regulators of protein tyrosine phosphorylation. More than merely terminating the pathways initiated by protein-tyrosine kinases, phosphatases are active participants in many signaling pathways. Signals involving tyrosine phosphorylation are frequently generated in response to cell-matrix adhesion. In addition, high levels of protein tyrosine phosphorylation generally promote disassembly or turnover of adhesions. In this brief review, we will discuss the role of protein-tyrosine phosphatases in cell-matrix adhesions.
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