期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 203, 期 6, 页码 1407-1412出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20060206
关键词
-
资金
- NIAID NIH HHS [R01 AI055472] Funding Source: Medline
Caspase-1 is activated by a variety of stimuli after the assembly of the inflammasome, an activating platform made up of a complex of the NOD-LRR family of proteins. Caspase-1 is required for the secretion of proinflammatory cytokines, such as interleukin ( IL)-1 beta and IL-18, and is involved in the control of many bacterial infections. Paradoxically, however, its absence has been reported to confer resistance to oral infection by Salmonella typhimurium. We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据