期刊
BRAIN RESEARCH
卷 1094, 期 -, 页码 86-91出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2006.03.118
关键词
tryptophan; striatum; nucleus accumbens; serotonin; dopamine release; locomotor activity
The present study examined the effects of a tryptophan-deficient diet on behavioral and neurochemical response to amphetamine. A tryptophan-deficient diet (14 days) decreased striatal serotonin and 5-hydroxyindolacetic acid content in rats. Under the latter conditions, amphetamine increased dopamine efflux in striatum and nucleus accumbens and produced a greater increase in motor activity when compared to controls. These results indicate how response to psychostimulants might be altered in the presence of a tryptophan-deficient diet. (c) 2006 Elsevier B.V. All rights reserved.
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