期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 128, 期 23, 页码 7486-7491出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja056780z
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Two antimycobacterial agents, lariatins A and B, were isolated from the culture broth of Rhodococcus sp. K01-B0171. Their structures were elucidated by spectral analysis and advanced protein chemical methods to be unique cyclic peptides, which consist of 18 and 20 L-amino acid residues with an internal linkage between the gamma-carboxyl group of Glu8 and the alpha-amino group of Gly1. The three-dimensional structure of lariatin A deduced from NMR data by dynamical simulated annealing method indicates that the tail segment ( Trp9-Pro18) passes through the ring segment ( Gly1-Glu8) to form a 'lasso' structure.
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