期刊
JOURNAL OF INFECTIOUS DISEASES
卷 193, 期 12, 页码 1619-1625出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/504268
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资金
- NCI NIH HHS [CA 18029, P01 CA018029, P30 CA015704, CA 15704] Funding Source: Medline
- NHLBI NIH HHS [K23HL69860, HL081595, K23 HL069860, R01 HL081595] Funding Source: Medline
We conducted a 12-year retrospective study to determine the effects that the community respiratory-virus species and the localization of respiratory-tract virus infection have on severe airflow decline, a serious and fatal complication occurring after hematopoietic cell transplantation (HCT). Of 132 HCT recipients with respiratory-tract virus infection during the initial 100 days after HCT, 50 (38%) developed airflow decline <= 1 year after HCT. Lower-respiratory-tract infection with parainfluenza (odds ratio [OR], 17.9 [95% confidence interval {CI}, 2.0-160]; P = .01) and respiratory syncytial virus (OR, 3.6 [95% CI, 1.0-13]; P = .05) independently. increased the risk of development of airflow decline <= 1 year after HCT. The airflow decline was immediately detectable after infection and was strongest for lower-respiratory-tract infection with parainfluenza virus; it stabilized during the months after the respiratory-tract virus infection, but, at <= 1 year after HCT, the initial lung function was not restored. Thus, community respiratory virus-associated airflow decline seems to be specific to viral species and infection localization.
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