期刊
CELL CYCLE
卷 5, 期 12, 页码 1313-1319出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.5.12.2863
关键词
Akt/PKB; p21 Cip1 Waf1 Sdi1; cyclin; cdk; cell cycle; phosphorylation; degradation; protein/protein interaction; PKC; p27 Kip1
类别
资金
- Biotechnology and Biological Sciences Research Council [BB/C508134/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/C508134/1] Funding Source: Medline
p21 was originally described as functioning as a cell cycle regulator via inhibition of both cyclin-dependent kinases and processive DNA replication. Nowadays it is recognized to play other fundamental roles including transcriptional regulation and the modulation of apoptosis. Each of these functions of p21 is achieved through direct p21/protein interactions and the subcellular localization of p21 plays an important part in dictating the binding partners to which p21 is exposed. Over recent years, a number of phosphorylation sites in p21 have been identified, these being targeted by several important intracellular signalling protein kinases. Here we review the state of our knowledge of p21 phosphorylation with respect to the kinases involved and the molecular biological effects of each phosphorylation event.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据